Have an Autoimmune Disease? Blame the Black Death

The bubonic plague killed so many people in Europe, the Middle East, and North Africa that that natural selection event is still rippling through our genomes today. But the same genes that helped your ancestors survive the Black Death may be contributing to autoimmune disease today.

Hosted by: Stefan Chin (he/him)
----------
Support SciShow by becoming a patron on Patreon: https://www.patreon.com/scishow
----------
Huge thanks go to the following Patreon supporters for helping us keep SciShow free for everyone forever: Adam Brainard, Alex Hackman, Ash, Bryan Cloer, charles george, Chris Mackey, Chris Peters, Christoph Schwanke, Christopher R Boucher, Eric Jensen, Harrison Mills, Jaap Westera, Jason A, Saslow, Jeffrey Mckishen, Jeremy Mattern, Kevin Bealer, Matt Curls, Michelle Dove, Piya Shedden, Rizwan Kassim, Sam Lutfi
----------
Looking for SciShow elsewhere on the internet?
SciShow Tangents Podcast: https://scishow-tangents.simplecast.com/
TikTok: https://www.tiktok.com/@scishow
Twitter: http://www.twitter.com/scishow
Instagram: http://instagram.com/thescishow
Facebook: http://www.facebook.com/scishow

#SciShow #science #education #learning #complexly
----------
Sources:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9932995/
https://www.nih.gov/news-events/nih-research-matters/how-black-death-shaped-human-evolution
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9580435/
https://www.ncbi.nlm.nih.gov/gene/64167
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10119032/
https://ojrd.biomedcentral.com/articles/10.1186/s13023-019-1127-0
https://www.pfizer.com/news/articles/is_rheumatoid_arthritis_genetic_or_hereditary#:~:text=HLA%2DDR4%E2%80%94This%20is%20the,and%20symptoms%20may%20be%20worse
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4752571/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5751129/
https://medlineplus.gov/genetics/condition/multiple-sclerosis/#causes
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7513766/
https://www.science.org/content/article/there-are-about-20000-human-genes-so-why-do-scientists-only-study-small-fraction-them
https://www.sciencedirect.com/topics/medicine-and-dentistry/antagonistic-pleiotropy
https://www.nature.com/scitable/topicpage/pleiotropy-one-gene-can-affect-multiple-traits-569/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3254080/
https://www.nih.gov/news-events/news-releases/nih-study-shows-genomic-variation-causing-common-autoinflammatory-disease-may-increase-resilience-bubonic-plague


Image Sources:
https://commons.wikimedia.org/wiki/File:Doutielt3.jpg
https://tinyurl.com/43udjhk5
https://commons.wikimedia.org/wiki/File:Bubonic_plague_map_2.png
https://www.gettyimages.com/detail/photo/brown-rat-in-darkness-walking-in-water-royalty-free-image/1452465372?phrase=plague+rat&adppopup=true
https://www.gettyimages.com/detail/photo/pet-rat-human-skull-royalty-free-image/1264180187?phrase=black+death&adppopup=true
https://www.gettyimages.com/detail/video/cemetery-graveyard-tombstones-rising-pan-scene-halloween-stock-footage/1217911769?adppopup=true
https://www.gettyimages.com/detail/photo/sequence-royalty-free-image/498188318?phrase=dna+genes&adppopup=true
https://www.gettyimages.com/detail/video/bases-with-deoxyribonucleic-acid-molecule-rotate-on-stock-footage/1709305492?adppopup=true
https://www.gettyimages.com/detail/photo/microscope-royalty-free-image/493957253?phrase=microscope&adppopup=true
https://www.gettyimages.com/detail/illustration/immune-response-and-antigen-presentation-royalty-free-illustration/1256692927?phrase=antigen+presenting+cell&adppopup=true
https://www.gettyimages.com/detail/illustration/immune-system-royalty-free-illustration/884651112?phrase=immune+system&adppopup=true
https://commons.wikimedia.org/wiki/File:Black_death_XV.jpg
https://www.gettyimages.com/detail/photo/gastroenterology-consultation-anatomical-intestines-royalty-free-image/1401368835?phrase=Crohn%27s+disease&adppopup=true
https://www.gettyimages.com/detail/video/microscopic-bacteria-medical-background-stock-footage/519456917?adppopup=true
https://www.gettyimages.com/detail/video/antibodies-block-a-virus-from-entering-a-body-cell-stock-footage/1221226197?adppopup=true
https://www.gettyimages.com/detail/video/colorful-dna-element-motion-stock-footage/932150052?adppopup=true
https://www.gettyimages.com/detail/photo/ancient-artifacts-in-akrotiri-santorini-royalty-free-image/521801503?phrase=akrotiri&adppopup=true
https://www.gettyimages.com/detail/video/virus-cells-floating-in-mid-air-3d-render-stock-footage/1212544935?adppopup=true
https://www.gettyimages.com/detail/photo/stomach-pains-royalty-free-image/1412268592?phrase=crohn%27s+disease&adppopup=true
https://www.gettyimages.com/detail/illustration/dna-royalty-free-illustration/484011593?phrase=dna&adppopup=true
https://commons.wikimedia.org/wiki/File:Peste_bubonique_-_enluminure.jpg
https://www.gettyimages.com/detail/photo/collection-set-old-parchment-paper-sheet-vintage-royalty-free-image/1438886935?phrase=medieval&adppopup=true