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Petri dishes contaminated with the wrong cell lines have compromised thousands of studies, leaving us with questionable treatments for a variety of diseases. How do we solve this enormous, microscopic problem?
Hosted by: Hank Green (he/him)
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Support SciShow by becoming a patron on Patreon: https://www.patreon.com/scishow
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Huge thanks go to the following Patreon supporters for helping us keep SciShow free for everyone forever: Matt Curls, Alisa Sherbow, Dr. Melvin Sanicas, Harrison Mills, Adam Brainard, Chris Peters, charles george, Piya Shedden, Alex Hackman, Christopher R, Boucher, Jeffrey Mckishen, Ash, Silas Emrys, Eric Jensen, Kevin Bealer, Jason A Saslow, Tom Mosner, Tomás Lagos González, Jacob, Christoph Schwanke, Sam Lutfi, Bryan Cloer
----------
Sources:
The Immortal Life of Henrietta Lacks: https://rebeccaskloot.com/the-immortal-life/about-the-book/
https://www.atcc.org/services/cell-authentication/human-cell-str-testing
https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.2001438
https://www.technologynetworks.com/cell-science/how-to-guides/how-to-prevent-cell-culture-contamination-htg-299231
https://handling-solutions.eppendorf.com/cell-handling/identity/scientific-background/str-profiling/
https://www.nytimes.com/2001/07/02/us/lewis-l-coriell-90-virologist-who-set-stage-for-polio-vaccine.html
https://safety.fsu.edu/safety_manual/supporting_docs/Understanding%20and%20Managing%20Cell%20Culture%20Contamination.pdf
https://www.ncbi.nlm.nih.gov/books/NBK144066/
http://medcraveonline.com/JSRT/JSRT-01-00031.pdf
https://scholar.google.com/scholar?hl=en&as_sdt=0%2C5&as_ylo=2019&q=%22INT+407%22+crohn%27s&btnG=
https://journals.sagepub.com/doi/pdf/10.1177/24725552211051963
https://www.sigmaaldrich.com/GB/en/product/sigma/85051004
https://iclac.org/education/wsu-cll/
https://iclac.org/databases/cross-contaminations/
https://www.statnews.com/2016/07/21/studies-wrong-cells/
https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.2001438
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5638414/
https://pubmed.ncbi.nlm.nih.gov/12200708/
https://www.science.org/doi/pdf/10.1126/science.347.6225.938
https://www.atcc.org/services/cell-authentication/human-cell-str-testing
https://www.future-science.com/doi/10.2144/000112598
https://www.leica-microsystems.com/science-lab/how-to-do-a-proper-cell-culture-quick-check/
https://meridian.allenpress.com/aplm/article/133/9/1463/460899/Henrietta-Lacks-HeLa-Cells-and-Cell-Culture
https://academic.oup.com/jnci/article-abstract/28/1/147/882682
https://www.technologynetworks.com/cell-science/how-to-guides/how-to-prevent-cell-culture-contamination-htg-299231
https://www.thermofisher.com/uk/en/home/references/gibco-cell-culture-basics/biological-contamination.html
https://www.biocompare.com/pfu/111694/soids/36174-2259403/Cells_and_Microorganisms/Human_Cell_Lines
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3341241/
https://pubmed.ncbi.nlm.nih.gov/20686743/
https://www.theguardian.com/world/2010/apr/04/henrietta-lacks-cancer-cells
https://web.archive.org/web/20161125100920/http://pilotonline.com/news/local/health/cancer-cells-killed-henrietta-lacks---then-made-her/article_17bd351a-f606-54fb-a499-b6a84cb3a286.html
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2136303/
https://www.ncbi.nlm.nih.gov/books/NBK144066/
Image Sources:
https://bit.ly/41nlZUu
https://bit.ly/3MzGgCg
https://bit.ly/41lFEUZ
https://bit.ly/3UrMs0Y
https://bit.ly/3MENchs
https://bit.ly/3UB8TB1
https://www.flickr.com/photos/nihgov/42111492701/in/album-72157658500115374/
https://bit.ly/3mra21r
https://bit.ly/3KsYfrm
https://bit.ly/3GBcqJW
https://commons.wikimedia.org/wiki/File:Pancreatic_cells_-_TEM.jpg
https://bit.ly/3KPj6GP
https://commons.wikimedia.org/wiki/File:Generic_Drug_Research_(5956)_(8493712946).jpg
https://bit.ly/3mj18TO
https://bit.ly/3ZZYyzI
https://bit.ly/41j2o7Z
https://bit.ly/4120CIT
https://bit.ly/3ZUFdjm
https://bit.ly/41ddhIM
https://bit.ly/3KucV9M
https://bit.ly/43jSxAR
https://bit.ly/3KsvD1C
https://commons.wikimedia.org/wiki/File:Diethylstilbestrol_(des)_cervix_(52).jpg
https://bit.ly/3KuFLa7
https://commons.wikimedia.org/wiki/File:Cancer_cells_(1).jpg
https://bit.ly/41hQ87R
https://bit.ly/3zQq5ZH
https://bit.ly/43osbxz
https://bit.ly/3UvnuxV
https://bit.ly/3zQqf3f
https://bit.ly/3Kxt9Pi
https://bit.ly/3zOMeYe
https://bit.ly/3KTxqxO
https://bit.ly/3GxBj9e
https://bit.ly/401sHP1
https://bit.ly/41mc0z6
https://bit.ly/4095JWw
https://bit.ly/3o7WBno
https://bit.ly/401rwzf
https://bit.ly/3UrOjD4
https://bit.ly/3KyDfiW
https://bit.ly/3mptD1Y
https://bit.ly/3nWUiUa
Petri dishes contaminated with the wrong cell lines have compromised thousands of studies, leaving us with questionable treatments for a variety of diseases. How do we solve this enormous, microscopic problem?
Hosted by: Hank Green (he/him)
----------
Support SciShow by becoming a patron on Patreon: https://www.patreon.com/scishow
----------
Huge thanks go to the following Patreon supporters for helping us keep SciShow free for everyone forever: Matt Curls, Alisa Sherbow, Dr. Melvin Sanicas, Harrison Mills, Adam Brainard, Chris Peters, charles george, Piya Shedden, Alex Hackman, Christopher R, Boucher, Jeffrey Mckishen, Ash, Silas Emrys, Eric Jensen, Kevin Bealer, Jason A Saslow, Tom Mosner, Tomás Lagos González, Jacob, Christoph Schwanke, Sam Lutfi, Bryan Cloer
----------
Sources:
The Immortal Life of Henrietta Lacks: https://rebeccaskloot.com/the-immortal-life/about-the-book/
https://www.atcc.org/services/cell-authentication/human-cell-str-testing
https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.2001438
https://www.technologynetworks.com/cell-science/how-to-guides/how-to-prevent-cell-culture-contamination-htg-299231
https://handling-solutions.eppendorf.com/cell-handling/identity/scientific-background/str-profiling/
https://www.nytimes.com/2001/07/02/us/lewis-l-coriell-90-virologist-who-set-stage-for-polio-vaccine.html
https://safety.fsu.edu/safety_manual/supporting_docs/Understanding%20and%20Managing%20Cell%20Culture%20Contamination.pdf
https://www.ncbi.nlm.nih.gov/books/NBK144066/
http://medcraveonline.com/JSRT/JSRT-01-00031.pdf
https://scholar.google.com/scholar?hl=en&as_sdt=0%2C5&as_ylo=2019&q=%22INT+407%22+crohn%27s&btnG=
https://journals.sagepub.com/doi/pdf/10.1177/24725552211051963
https://www.sigmaaldrich.com/GB/en/product/sigma/85051004
https://iclac.org/education/wsu-cll/
https://iclac.org/databases/cross-contaminations/
https://www.statnews.com/2016/07/21/studies-wrong-cells/
https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.2001438
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5638414/
https://pubmed.ncbi.nlm.nih.gov/12200708/
https://www.science.org/doi/pdf/10.1126/science.347.6225.938
https://www.atcc.org/services/cell-authentication/human-cell-str-testing
https://www.future-science.com/doi/10.2144/000112598
https://www.leica-microsystems.com/science-lab/how-to-do-a-proper-cell-culture-quick-check/
https://meridian.allenpress.com/aplm/article/133/9/1463/460899/Henrietta-Lacks-HeLa-Cells-and-Cell-Culture
https://academic.oup.com/jnci/article-abstract/28/1/147/882682
https://www.technologynetworks.com/cell-science/how-to-guides/how-to-prevent-cell-culture-contamination-htg-299231
https://www.thermofisher.com/uk/en/home/references/gibco-cell-culture-basics/biological-contamination.html
https://www.biocompare.com/pfu/111694/soids/36174-2259403/Cells_and_Microorganisms/Human_Cell_Lines
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3341241/
https://pubmed.ncbi.nlm.nih.gov/20686743/
https://www.theguardian.com/world/2010/apr/04/henrietta-lacks-cancer-cells
https://web.archive.org/web/20161125100920/http://pilotonline.com/news/local/health/cancer-cells-killed-henrietta-lacks---then-made-her/article_17bd351a-f606-54fb-a499-b6a84cb3a286.html
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2136303/
https://www.ncbi.nlm.nih.gov/books/NBK144066/
Image Sources:
https://bit.ly/41nlZUu
https://bit.ly/3MzGgCg
https://bit.ly/41lFEUZ
https://bit.ly/3UrMs0Y
https://bit.ly/3MENchs
https://bit.ly/3UB8TB1
https://www.flickr.com/photos/nihgov/42111492701/in/album-72157658500115374/
https://bit.ly/3mra21r
https://bit.ly/3KsYfrm
https://bit.ly/3GBcqJW
https://commons.wikimedia.org/wiki/File:Pancreatic_cells_-_TEM.jpg
https://bit.ly/3KPj6GP
https://commons.wikimedia.org/wiki/File:Generic_Drug_Research_(5956)_(8493712946).jpg
https://bit.ly/3mj18TO
https://bit.ly/3ZZYyzI
https://bit.ly/41j2o7Z
https://bit.ly/4120CIT
https://bit.ly/3ZUFdjm
https://bit.ly/41ddhIM
https://bit.ly/3KucV9M
https://bit.ly/43jSxAR
https://bit.ly/3KsvD1C
https://commons.wikimedia.org/wiki/File:Diethylstilbestrol_(des)_cervix_(52).jpg
https://bit.ly/3KuFLa7
https://commons.wikimedia.org/wiki/File:Cancer_cells_(1).jpg
https://bit.ly/41hQ87R
https://bit.ly/3zQq5ZH
https://bit.ly/43osbxz
https://bit.ly/3UvnuxV
https://bit.ly/3zQqf3f
https://bit.ly/3Kxt9Pi
https://bit.ly/3zOMeYe
https://bit.ly/3KTxqxO
https://bit.ly/3GxBj9e
https://bit.ly/401sHP1
https://bit.ly/41mc0z6
https://bit.ly/4095JWw
https://bit.ly/3o7WBno
https://bit.ly/401rwzf
https://bit.ly/3UrOjD4
https://bit.ly/3KyDfiW
https://bit.ly/3mptD1Y
https://bit.ly/3nWUiUa
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- Documentary
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- SciShow, science, Hank
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