These AIs Are About to Revolutionize Biology

Even though proteins are fundamental to life, it’s hard to predict what they look like. But two independent groups announced that they’d cracked it, and it’s all thanks to some seriously clever artificial intelligence.

Hosted by: Hank Green

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Sources:
https://www.nature.com/articles/s41586-021-03819-2
https://www.nature.com/articles/d41586-021-01968-y
https://science.sciencemag.org/content/early/2021/07/14/science.abj8754
https://www.sciencemag.org/news/2021/07/researchers-unveil-phenomenal-new-ai-predicting-protein-structures
https://www.ipd.uw.edu/2021/07/rosettafold-accurate-protein-structure-prediction-accessible-to-all/
https://www.thetimes.co.uk/article/demis-hassabis-interview-the-kid-from-the-comp-who-founded-deepmind-and-cracked-a-mighty-riddle-of-science-g3v3z9b80
https://www.technologyreview.com/2020/11/12/1011944/artificial-intelligence-replication-crisis-science-big-tech-google-deepmind-facebook-openai/
https://www.technologyreview.com/2020/11/30/1012712/deepmind-protein-folding-ai-solved-biology-science-drugs-disease/
https://news.cancerresearchuk.org/2020/12/23/what-could-deepmind-solving-the-protein-folding-problem-mean-for-cancer-research/
https://www.theguardian.com/technology/2020/nov/30/deepmind-ai-cracks-50-year-old-problem-of-biology-research
https://arstechnica.com/science/2021/07/google-details-its-protein-folding-software-academics-offer-an-alternative/
https://www.vox.com/future-perfect/22045713/ai-artificial-intelligence-deepmind-protein-folding
https://deepmind.com/blog/article/alphafold-a-solution-to-a-50-year-old-grand-challenge-in-biology
https://www.pnas.org/content/117/3/1496
https://emerj.com/ai-sector-overviews/deepmind-alphafold/
https://www.chemistryworld.com/opinion/behind-the-screens-of-alphafold/4012867.article
https://www.dw.com/en/what-are-proteins-and-why-do-they-fold/a-55815679
https://www.nature.com/articles/d41586-020-03348-4

https://www.nature.com/articles/s41586-021-03828-1
https://www.nature.com/articles/d41586-021-02025-4
https://www.theguardian.com/technology/2021/jul/22/ai-firm-deepmind-puts-database-building-blocks-life-human-protein-structure-free-online
https://www.nature.com/articles/d41586-021-02037-0

http://www.imgt.org/IMGTeducation/Aide-memoire/_UK/aminoacids/abbreviation.html
https://www.ncbi.nlm.nih.gov/books/NBK26830/
https://predictioncenter.org/casp14/doc/CASP14_press_release.html
https://www.youtube.com/watch?v=gg7WjuFs8F4
https://deepmind.com/blog/article/AlphaStar-Grandmaster-level-in-StarCraft-II-using-multi-agent-reinforcement-learning
https://deepmind.com/blog/article/alphazero-shedding-new-light-grand-games-chess-shogi-and-go
https://www.nobelprize.org/prizes/chemistry/1972/summary/
https://www.frontiersin.org/articles/10.3389/fmolb.2020.00009/full
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7402234/
https://www.youtube.com/watch?v=gLsC4wlrR2A
https://www.nature.com/articles/d41586-021-02265-4

Images:
https://commons.wikimedia.org/wiki/File:Hexokinase_ball_and_stick_model,_with_substrates_to_scale_copy.png
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https://commons.wikimedia.org/wiki/File:Target3dsmRib_354predictedModels_CASP8.jpg
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https://commons.wikimedia.org/wiki/File:[email protected]
https://commons.wikimedia.org/wiki/File:Structural_coverage_of_the_human_cyclophilin_family.png
https://commons.wikimedia.org/wiki/File:Protein_Imager_molecular_rendering_example_3_CsgFG_complex.png
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https://commons.wikimedia.org/wiki/File:Chaperonin_1AON.png
https://commons.wikimedia.org/wiki/File:Protein_structure_examples.png