Loose vs Lose: What's the Difference? Basic English Grammar

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In this video, Alisha answers 5 questions.
- What's the difference between afraid and scared? I am a little confused.
- Can you tell me the difference between the words "commitment" and "compromise", please?
- What is the difference between "supposed to" and "meant to"?
- Is there any difference between loose and lose? I'm also confused with the words uninterested and disinterested. I think they have the same meaning, but I'm not sure...
- I found that sometimes there is a comma before "and", but sometimes not. When should I add a comma before "and"?
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